Progressive Caloric Restriction Induces Dose-Dependent Changes in Myocardial Triglyceride Content and Diastolic Function in Healthy Men
نویسندگان
چکیده
منابع مشابه
Short-term caloric restriction induces accumulation of myocardial triglycerides and decreases left ventricular diastolic function in healthy subjects.
OBJECTIVE Diabetes and obesity are associated with increased plasma nonesterified fatty acid (NEFA) levels, myocardial triglyceride accumulation, and myocardial dysfunction. Because a very low-calorie diet (VLCD) also increases plasma NEFA levels, we studied the effect of a VLCD on myocardial triglyceride content and cardiac function in healthy subjects. RESEARCH DESIGN AND METHODS Fourteen h...
متن کاملFunctional and metabolic imaging of the right ventricle: short-term caloric restriction increases myocardial triglyceride content and decreases diastolic heart function
Background Caloric restriction increases plasma non-esterified fatty acid (NEFA) levels, and increases myocardial triglyceride content. It has been shown that elevated levels of NEFA’s in patients with metabolic disease (metabolic syndrome/ type 2 diabetes mellitus) are associated with a decrease in left ventricular function. However little is known about its effects on right ventricular functi...
متن کاملAssociation between Myocardial Triglyceride Content and Cardiac Function in Healthy Subjects and Endurance Athletes
Ectopic fat accumulation plays important roles in various metabolic disorders and cardiovascular diseases. Recent studies reported that myocardial triglyceride (TG) content measured by proton magnetic resonance spectroscopy ((1)H-MRS) is associated with aging, diabetes mellitus, and cardiac dysfunction. However, myocardial TG content in athletes has not yet been investigated. We performed (1)H-...
متن کاملThe ageing male heart: myocardial triglyceride content as independent predictor of diastolic function.
AIMS In animal models of obesity and diabetes mellitus, myocardial TG accumulation is associated with decreased myocardial function. In the physiologically ageing heart, myocardial triglyceride (TG) accumulation may also occur due to reduced myocardial fatty acid oxidation. The role of myocardial TG in the ageing human heart is unknown. Therefore, the purpose of our study was to evaluate the ef...
متن کاملLong-term caloric restriction ameliorates the decline in diastolic function in humans.
OBJECTIVES We determined whether caloric restriction (CR) has cardiac-specific effects that attenuate the established aging-associated impairments in diastolic function (DF). BACKGROUND Caloric restriction retards the aging process in small mammals; however, no information is available on the effects of long-term CR on human aging. In healthy individuals, Doppler echocardiography has establis...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 2008
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jc.2007-2015